Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides that show angiogenic and mitogenic activities. The significance of VEGFs and receptors in tumorigenesis, angiogenesis, and neuroprotection makes them interesting targets for drug development.
The VEGF family members VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF attach in distinct patterns to three related receptor protein tyrosine kinases —VEGFR1/FLT1, VEGFR2/KDR, and VEGFR3/FLT4 — and two non-tyrosine kinase transmembrane proteins, neuropilin-1 (NRP1) and neuropilin-2 (NRP2).
The ligand-receptor attachment triggers the formation of homo- and heteromeric receptor complexes and enables downstream signaling.
Along with VEGF signaling, neuropilins also serve as co-receptors to various other signaling pathways, like those activated by Fibroblast Growth Factor (FGF), Insulin-like Growth Factor (IGF), Transforming Growth Factor beta (TGFβ), Hepatocyte Growth Factor (HGF), and Platelet-Derived Growth Factor (PDGF).
VEGF family ligands and receptors
More than 65 recombinant VEGF and receptor proteins that cover all VEGF family members and various isoforms of VEGF are provided by Sino Biological.
A great majority of these recombinant proteins are expressed in eukaryotic cells (human cells or insect cells), which affirms the right modification and greater activity of proteins.
High activity
Cell proliferation assay using human umbilical vein endothelial cells (HUVEC). Image Credit: Sino Biological Inc.
Inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC). Image Credit: Sino Biological Inc.
Recommended recombinant VEGF and receptor proteins
Source: Sino Biological Inc.
| Cat# |
Molecule |
Species |
Activity |
Tag |
| 10136-H02H |
VEGFR1/FLT-1 |
Human |
Active |
hFc |
| 10136-H08H |
VEGFR1/FLT-1 |
Human |
Active |
His |
| 10136-H08H1 |
VEGFR1/FLT-1 |
Human |
Active |
His |
| 10806-H02H |
VEGFR3/FLT4 (ECD) |
Human |
Active |
hFc |
| 50584-M02H |
VEGFR3/FLT-4 |
Mouse |
Active |
hFc |
| 10012-H02H |
VEGFR2/KDR |
Human |
Active |
hFc |
| 10012-H02H1 |
VEGFR2/KDR (Domain 1&2&3) |
Human |
Active |
hFc |
| 10012-H02H1-B |
VEGFR2/KDR (Domain 1&2&3) |
Human |
|
hFc |
| 10012-H02H2 |
VEGFR2/KDR (Domain 2&3) |
Human |
Active |
hFc |
| 10012-H08H2 |
VEGFR2/KDR (Domain 2&3) |
Human |
|
His |
| 10012-H20B1 |
VEGFR2/KDR |
Human |
Active |
GST &
His |
| 50998-M08H-B |
VEGFR2/KDR |
Mouse |
Active |
His |
| 80113-R02H |
VEGFR2/KDR |
Rat |
Active |
hFc |
| 80113-R08H |
VEGFR2/KDR |
Rat |
|
His |
| 90907-C08H |
VEGFR2/KDR |
Cynomolgus |
|
His |
| 10011-H08H |
NRP1 |
Human |
Active |
His |
| 10695-H02H |
NRP2 |
Human |
Active |
hFc |
| 11066-HNAB-B |
VEGF165 |
Human,
Cynomolgus |
|
Native |
| 11066-HNAH |
VEGF165 |
Human,
Cynomolgus |
Active |
Native |
| 63004-ZNAB |
VEGF165 |
Danio rerio
(zebrafish) |
Active |
Native |
| 70004-DNAH |
VEGF164 |
Canine |
Active |
Native |
| 80006-RNAB |
VEGF164 |
Rat |
Active |
Native |
| 10544-H01H |
VEGFB |
Human |
Active |
hFc |
| 80103-R01H |
VEGFC (aa 108-223) |
Mouse, Rat |
Active |
hFc |
| 80103-R08H |
VEGFC (aa 108-223) |
Mouse, Rat |
Active |
His |
| 50157-M01H |
VEGFD |
Mouse |
Active |
hFc |
| 50157-M08H |
VEGFD |
Mouse |
Active |
His |
| 80104-R01H |
VEGFD |
Rat |
Active |
hFc |
| 10274-H05H |
PIGF |
Human |
Active |
mFc |
VEGF/VEGFR antibodies
Sino Biological provides more than 100 antibodies against VEGF and receptor proteins with affirmed activities in numerous applications. The applications include immunohistochemistry, immunofluorescence, western blotting, flow cytometry, neutralization, and ELISA. The company also offers ELISA kits and ELISA pair sets.
The Global Leader in Recombinant Technology
Video credit: Sino Biological