Targeting biomarkers in head and neck cancer: FGFR1, KLK6, Osteonectin

Head and neck cancer (HNC) is a heterogeneous disease affecting multiple sites and cellular origins of the head and neck, including the paranasal sinuses, nasal cavity, tongue, oral cavity, larynx, pharynx, and salivary glands.

It accounts for 4% of all cancer cases in the United States and is the sixth deadliest cancer in the world. Early detection is essential for enhancing treatment outcomes, emphasizing the importance of developing new diagnostics and therapeutics.

Aside from proven biomarkers, such as MMP9, EGFR, CDKN2A, and VEGF, emerging biomarkers and drug targets like CXCR4/CD184, cIAP1, KLK6, FGFR1, XIAP, Osteonectin, BCL-2, S100A9, c-MET, FGFR3, CD44, Alpha-fetoprotein, IL-8/CXCL8, Beta-Tubulin, PFN1, and cyclin D1 provide innovative opportunities for the development of treatments options.

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Sino Biological provides high-quality antibodies, recombinant proteins, and ELISA kits to assist head and neck cancer research.

Figure 1. Emerging biomarkers in head and neck cancer. Image Credit: Sino Biological Inc.

Featured recombinant HNC biomarker proteins

Sino Biological provides high-quality recombinant proteins to assist head and neck cancer research.

• High-purity
• Activity-validated
• Low-endotoxin
• Cited by researchers

Human S100A9 protein (Cat#: 11145-H08B)

Immobilized S100A8 protein can bind to human S100A9 protein. Image Credit: Sino Biological Inc.

Human BCL-2 protein (Cat#: 10195-H08E)

Immobilized human BCL2 protein can bind Mouse BCL2L1 protein (Cat#: 50012-M08E). Image Credit: Sino Biological Inc.

Human FGFR3 protein (Cat#: 16486-H02H)

Ability to inhibit FGF-acidic-dependent proliferation of Balb/c 3T3 mouse fibroblasts. Image Credit: Sino Biological Inc.

Human FGFR1 protein (Cat#: 10616-H08H)

Ability to inhibit FGF acidic-dependent proliferation of Balb/C 3T3 mouse fibroblasts. Image Credit: Sino Biological Inc.

Human CXCR4/CD184 protein (Cat#: 11325-HNAH) HPLC verified

Immobilized human CXCR4/CD184 protein-VLP can bind anti-human CXCR4/CD184 Antibody. Image Credit: Sino Biological Inc.

Human IL-8/CXCL8 protein (Cat#: 10098-HNCH2)

Immobilized human IL-8/CXCL8 can bind anti-IL-8/CXCL8 antibody (Cat#: 10098-MM18). Image Credit: Sino Biological Inc.

More recombinant HNC biomarker proteins (partial)

Table 1. Source: Sino Biological Inc.

Featured antibodies against HNC biomarkers

Sino Biological has created a panel of antibodies with multiple applications, including ELISA, ICC/IF, IHC-P, FCM, IP, and WB, to assist head and neck cancer research.

Anti-PFN1 antibody

• Cat#: 107394-T40
• Type: Rabbit PAb
• Ig Type: Rabbit IgG
• Applications: WB, IHC-P

Immunochemical staining of PFN1 in mouse colon. Image Credit: Sino Biological Inc.

Beta-Tubulin loading control antibody

• Cat#: 100109-MM05T
• Type: Mouse MAb
• Ig Type: Mouse IgG2b
• Applications: WB, IHC-P, IP, ICC/IF

Immunofluorescence staining of human Beta-Tubulin in HeLa cells. Image Credit: Sino Biological Inc.

Anti-c-MET antibody (PE)

• Cat#: 10692-R243-P
• Type: Rabbit MAb
• Ig Type: Rabbit IgG
• Applications: FCM

Profile of anti-human C-Met reactivity on HepG2 cells analyzed by flow cytometry. Image Credit: Sino Biological Inc.

CD44 matched ELISA antibody pair set

• Cat#: SEK12211
• Applications: Sandwich ELISA

Determination of the CD44 concentration. Image Credit: Sino Biological Inc.

More featured antibodies against HNC biomarkers (partial)

Table 2. Source: Sino Biological Inc.