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Selectins are a class of cell adhesion molecules that take part in the early stages of leukocyte–endothelium interactions. They play a vital role in the trafficking of innate immune system cells, platelets and T lymphocytes.

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Three groups of selectins exist: E-selectin (CD62E), P-selectin (CD62P) and L-selectin (CD62L). Each group interacts with its corresponding glycoprotein (mucin) ligands on particular tissues. The table below illustrates selectins and their counter receptors or ligands.

Table 1. Source: Sino Biological Inc.

Cat# Tissue Distribution Protein Ligands Major Inducers
P-selectin Activated endothelium and platelets PSGL-1, CD24 Thrombin, Histamine, Complement derivatives, Peroxides
E-selectin Activated endothelium PSGL-1, ESL-1, L-Selectin IL-1, TNF-α, LPS
L-selectin Memory lymphocytes, neutrophils, monocytes, macrophages, eosinophils PSGL-1, GlyCAM-1, MAdCAM-1, CD34, Podocalyxin IL-1, TNF-α, LPS, IFN-γ

 

Selectins play an active role in constitutive lymphocyte homing, cancer metastasis and chronic and acute inflammation. Thus, they are now the hot targets for developing therapeutics for the treatment of several diseases, like malignancies and sickle cell disease. Sino Biological offers a series of high-quality reagents to aid the study of ligands and selectins.

Selectins and ligands

Sino Biological has come up with a series of high-activity selectin and ligand proteins obtained from several species to help study the biology of selectins.

Recommended recombinant selectins and ligands proteins

Table 2. Source: Sino Biological Inc.

Cat# Molecule Species Activity Tag
50737-M02H Mouse P-selectin Active C-hFc
50737-M08H Mouse P-selectin Active C-His
80451-R02H Rat P-selectin Active C-hFc
80451-R08H Rat P-selectin   C-His
90170-C02H Rhesus P-selectin   C-hFc
90170-C08H Rhesus P-selectin   C-His
50736-M02H Mouse E-selectin Active C-hFc
50736-M08H Mouse E-selectin Active C-His
50736-MNAH Mouse E-selectin   Native
80033-R02H Rat E-selectin Active C-hFc
80033-R08H Rat E-selectin Active C-His
90169-C02H Cynomolgus E-selectin Active C-hFc
90169-C08H Cynomolgus E-selectin   C-His
11838-H08C Human L-selectin   C-His
50045-M03H Mouse L-selectin Active C-hFc & His
50045-M08H Mouse L-selectin   C-His
80046-R08H Rat L-selectin   C-His
90168-C02H Cynomolgus L-selectin Active C-hFc
90168-C08H Cynomolgus L-selectin   C-His
50770-M02H Mouse PSGL-1   C-hFc
50770-MCCH Mouse PSGL-1   C-cleavage

 

Selectin/ligand antibodies

Sino Biological has designed an extensive panel of antibodies for targeting ligands and selectins. These antibodies can be utilized in ELISA, FCM, WB and IP. Also, the company offers human, mouse and rat selectin ELISA kits and ELISA pair sets.

  • Anti-E-selectin
  • Anti-L-selectin
  • Anti-P-selectin
  • Anti-CD34
  • Anti-PSGL-1