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Microbial decoration enhances drug delivery specificity and safety

Announcing a new publication for Acta Materia Medica journal. Microorganisms are mostly distributed on the surface of our skin and intestines and have crucial roles in physiologic and metabolic processes, such as digestion and immunity, which are closely related to diseases.

29 Dec 2023

New study expands immunotherapy eligibility for colorectal and endometrial cancer patients

A new study shows thousands more patients diagnosed with colorectal and endometrial cancers could benefit from immunotherapy than are currently offered it.

29 Dec 2023

WVU expert offers tips on making lifestyle changes that have larger impact on long-term health

Bad news: if you are planning to start a diet as your New Year's resolution, you probably won't stick to it.

29 Dec 2023

Johns Hopkins researchers find minimal regret after gender affirming surgery

In a Viewpoint article published Dec. 27, 2023, in JAMA Surgery, three Johns Hopkins researchers urge the medical community to dismiss a widely held, but scientifically unsupported belief that many people who are transgender and gender diverse (TGD), and undergo gender affirming surgery (GAS), later regret their decision to undergo such procedures.

28 Dec 2023

'Visual system' protein appears to be key for stabilizing the body's circadian rhythms

Scientists at the Johns Hopkins University School of Medicine and the National Institutes of Health have identified a protein in the visual system of mice that appears to be key for stabilizing the body's circadian rhythms by buffering the brain's response to light.

28 Dec 2023

$15 million NCI grant awarded to investigate a type of radiation therapy for hard-to-treat cancers

The Radiopharmaceutical Therapy and Dosimetry Lab at Johns Hopkins Medicine, headed by George Sgouros, Ph.D., has been awarded a $15 million grant, to be dispersed over the next five years, from the National Cancer Institute at the National Institutes of Health.

28 Dec 2023

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

28 Dec 2023

Angelica gigas extract emerges as a potential treatment for vascular disease

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction."

28 Dec 2023

New insights on better diagnosis and treatment of ischemic cholecystitis

Ischemic cholecystitis is a form of gallbladder inflammation that occurs without gallstones or another form of external compression.

28 Dec 2023

AI advances could revolutionize hepatocellular carcinoma diagnosis

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. It is a major global health concern with rising rates, particularly in North Africa and East Asia.

28 Dec 2023

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

28 Dec 2023

$Lisocabtagene maraleucel: A cost-effective second-line treatment for relapsed/refractory DLBCL$

Lisocabtagene maraleucel: A cost-effective second-line treatment for relapsed/refractory DLBCL

Lisocabtagene maraleucel (liso-cel), a CAR T-cell therapy, is a cost effective second line treatment for relapsed and refractory (hard to treat) diffuse large B-cell lymphoma (r/r DLBCL), according to a study published today in Blood Advances.

28 Dec 2023

Integrated care may not be the silver bullet for mental health treatment, study finds

Health care systems in the United States have gradually embraced the concept that mental health should be treated on par with physical health, especially in light of increased rates of anxiety and depression during and after the COVID-19 pandemic.

28 Dec 2023

Next-gen sequencing identifies thousands of cancer patients missing out on immunotherapy

Brigham researchers' findings from next-generation sequencing suggest that revising current cancer care guidelines could allow approximately 6,000 more patients in the U.S. to benefit from immunotherapy treatment each year

28 Dec 2023

New non-steroidal anti-inflammatory can inhibit the cytokine storm and preserve innate immunity

Very early in the COVID-19 pandemic clinical trials in patients hospitalized with COVID-19 confirmed that corticosteroids like dexamethasone reduced mortality, but they were harmful when applied at the first COVID-19 symptoms, due to the weakening of innate antiviral immunity, leading to delayed viral clearance and adverse outcomes in severe viral pneumonias.

28 Dec 2023

Sepsis greatly reduces the chances of returning to work, study finds

A few years ago, the World Health Organization estimated that blood poisoning, or sepsis, is involved in one in five deaths in the world. 11 million people die from sepsis each year, of which nearly 3 million are children.

28 Dec 2023

Mental health courts can struggle to fulfill decades-old promise

In early December, Donald Brown stood nervously in the Hall County Courthouse, concerned he'd be sent back to jail.

28 Dec 2023

Plant-based fats and proteins shine in low-carb weight management

Low-carbohydrate diets comprised mostly of plant-based proteins and fats with healthy carbohydrates such as whole grains were associated with slower long-term weight gain than low-carbohydrate diets comprised mostly of animal proteins and fats with unhealthy carbohydrates like refined starches, according to a new study led by Harvard T.H. Chan School of Public Health.

27 Dec 2023

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition.

27 Dec 2023

Genetic clue to pericarditis inflammation points to promising new treatments

Sequence variants that protect against pericarditis have been discovered at a genomic locus encoding interleukin-1 immune cytokines.

27 Dec 2023

Medical News

Microbial decoration enhances drug delivery specificity and safety

New study expands immunotherapy eligibility for colorectal and endometrial cancer patients

WVU expert offers tips on making lifestyle changes that have larger impact on long-term health

Johns Hopkins researchers find minimal regret after gender affirming surgery

'Visual system' protein appears to be key for stabilizing the body's circadian rhythms

$15 million NCI grant awarded to investigate a type of radiation therapy for hard-to-treat cancers

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

Angelica gigas extract emerges as a potential treatment for vascular disease

New insights on better diagnosis and treatment of ischemic cholecystitis

AI advances could revolutionize hepatocellular carcinoma diagnosis

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Lisocabtagene maraleucel: A cost-effective second-line treatment for relapsed/refractory DLBCL

Integrated care may not be the silver bullet for mental health treatment, study finds

Next-gen sequencing identifies thousands of cancer patients missing out on immunotherapy

New non-steroidal anti-inflammatory can inhibit the cytokine storm and preserve innate immunity

Sepsis greatly reduces the chances of returning to work, study finds

Mental health courts can struggle to fulfill decades-old promise

Plant-based fats and proteins shine in low-carb weight management

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

Genetic clue to pericarditis inflammation points to promising new treatments

How medical manufacturing trends are evolving: From performance testing to 3D vision

Utilizing firefly liquid handling for laboratory developed tests

Immunopeptidomics offer new hope in cancer research

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