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Monkey stem cells made easy: New method unveils xeno-free, efficient culture system

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

22 Dec 2023

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

22 Dec 2023

Shedding new light on the hidden organization of the cytoplasm

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight.

21 Dec 2023

St. Jude researchers reveal structure of Parkinson's-linked proteins

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

21 Dec 2023

Basal spot junctions: A new player in epithelial adhesion and hippo signaling

Australian researchers have discovered a new way that epithelial cells, which form layers in organs like the skin and stomach, attach to one another, and how they perceive growth signals at these attachments, helping them form tissues of the right size and shape.

21 Dec 2023

Scientists develop a method for tracking cellular events over time in living organisms

While physicists continue to argue about whether time is indeed an illusion, as Albert Einstein claimed, biologists have no doubt about its significance for understanding life as a dynamic system.

21 Dec 2023

Scientists reprogram canine stem cells from urine

Dog owners may need to learn to appreciate their best friend's urine. Scientists at Osaka Metropolitan University have devised an efficient, non-invasive, and pain-free method to reprogram canine stem cells from urine samples, bringing furry companions one step closer to veterinary regenerative treatment.

21 Dec 2023

New tool organizes single-cell data for health discoveries

A new methodology that allows for the categorization and organisation of single-cell data has been launched. It can be used to create a harmonized dataset for the study of human health and disease.

21 Dec 2023

Deciphering how amino acids control cell growth and autophagy in yeast

Amino acids are the building blocks of life. We obtain them from the food we eat, and the body uses them to make proteins, which in turn are used for growth, development, and a multitude of other functions.

21 Dec 2023

Clearing the cellular clutter: New insights into how our cells stay healthy

If we don't take out the trash regularly, our homes become unpleasant and even a danger to our health.

20 Dec 2023

UW-Madison technology unveils autism gene's impact on early brain structure

Technology developed at the University of Wisconsin–Madison to grow "rosettes" of brain and spinal tissue gives scientists new ways to study the growing human brain, including a recent study of how genetic mutations linked to autism affect early stages of human brain development.

20 Dec 2023

Early embryo DNA replication program reveals unexpected flexibility

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next.

20 Dec 2023

New mechanism that regulates dietary lipid processing by the intestine revealed

The maintenance of a balanced lipid homeostasis is critical for our health. While consumption of excessive amounts of fatty foods contributes to metabolic diseases such as obesity and atherosclerosis, fat is an indispensable component of our diet.

20 Dec 2023

TMDU researchers develop novel method to identify protein-protein binding interfaces

Proteins are building blocks of our bodies, but they do not work solo. They form partners to facilitate in different biological processes that keep us going.

20 Dec 2023

First new antibiotic class in decades discovered using explainable AI platform

Scientists have discovered one of the first new classes of antibiotics identified in the past 60 years, and the first discovered leveraging an AI-powered platform built around explainable deep learning.

20 Dec 2023

New statistical technique improves disease prediction for people of African descent

A team of scientists from Icahn School of Medicine at Mount Sinai has developed a groundbreaking statistical technique, "BridgePRS," to enhance disease prediction in people of non-European ancestry, particularly those of African descent.

20 Dec 2023

Study reveals cytoglobin's pivotal role in cilia movement and organ positioning during development

Study reveals that cytoglobin (cygb2) plays a crucial role in regulating cilia motility and organ laterality during development, highlighting its importance in NO signaling and cilia function.

19 Dec 2023

Embryonic immune sensor could key to creating patient-derived blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

19 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Sirtuin 6: A potential savior for aging cartilage and osteoarthritis

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes."

19 Dec 2023