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Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.

2 Jan 2024

A protein identified as key player in keeping cells tidy

Just as healthy organs are vital to our well-being, healthy organelles are vital to the proper functioning of the cell.

2 Jan 2024

How immune cells shape our earliest breaths

Study profiles the development of immune cells in human lungs during embryonic and fetal stages, revealing their influence on epithelial cell fate and lung development.

1 Jan 2024

Catenane magic: Boosting protein stability and resilience with interlocking rings

This study is led by Prof. Wen-Bin Zhang (College of Chemistry and Molecular Engineering, Peking University & Beijing Academy of Artificial Intelligence) and Dr. Jing Fang (College of Chemistry and Molecular Engineering, Peking University).

29 Dec 2023

Mettl3 guides CD8 T cells to eliminate infected cells with maximum efficiency

This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr. Xuguang Du (College of Biological Sciences, China Agricultural University) and illustrated the key role of Mettl3 in CD8 T cell response during acute infection model.

29 Dec 2023

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

28 Dec 2023

Cadmium linked to DNA damage and morphological changes caused by particulate matter

Particulate matter causes health problems for those who inhale the fine droplets and particles, but the chemical composition of the mixture matters-;and can vary widely across space and time.

28 Dec 2023

New method designs high-affinity, orally bioavailable peptides

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy.

28 Dec 2023

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition.

27 Dec 2023

Genetic clue to pericarditis inflammation points to promising new treatments

Sequence variants that protect against pericarditis have been discovered at a genomic locus encoding interleukin-1 immune cytokines.

27 Dec 2023

Your unique microbiome may be used to improve and personalize your future medical experience

Study explores the potential of microbiomes in personalized medicine, focusing on diagnostics, precision therapy, and the challenges in implementing microbiome-based interventions.

27 Dec 2023

Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions

Research delves into the complex roles of neutrophils in inflammatory bowel disease (IBD), exploring their diverse functions and interactions with the gut microbiota and emphasizing the need for targeted therapies based on these insights.

27 Dec 2023

Common inflammation pathway turns anthrax toxin into killer

Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system.

26 Dec 2023

Research reveals how "forever chemicals" damage DNA at the molecular level

Recent research published in the journal Eco-Environment & Health (Volume 2, 2023) reveals groundbreaking insights into how typical PFAAs accelerate the degradation of DNA.

26 Dec 2023

Researchers receive two grants to study tuberculosis drug development

Weill Cornell Medicine researchers and the TB Drug Accelerator have received two grants totaling $6.8 million from the Bill & Melinda Gates Foundation to study tuberculosis (TB) drug development.

26 Dec 2023

Fox urine compound effectively repels flies through multisensory activation

Crop damage in agriculture and the transmission of vector-borne diseases by insect pests have become worldwide threat nowadays.

25 Dec 2023

Study identifies two stem cell types driving jellyfish tentacle growth

At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -; but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage.

25 Dec 2023

Study reveals how tiny tweaks to actin shape our cells

Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin.

22 Dec 2023

New family of polymers can kill bacteria without inducing antibiotic resistance

Antibiotic-resistant bacteria have become a rapidly growing threat to public health. Each year, they account for more than 2.8 million infections, according to the U.S. Centers for Disease Control and Prevention.

22 Dec 2023

Boosting egg production in fruit flies through gut bugs

For many of us, when we think of microbiomes, our first thoughts are probably about the beneficial microorganisms that live in our guts.

22 Dec 2023

Life Science News

Small molecule-switchable RNA platform enables control of therapeutic protein expression

A protein identified as key player in keeping cells tidy

How immune cells shape our earliest breaths

Catenane magic: Boosting protein stability and resilience with interlocking rings

Mettl3 guides CD8 T cells to eliminate infected cells with maximum efficiency

Insilico Medicine develops new AI-generated FGFR2/3 inhibitor for tissue-agnostic solid tumors

Cadmium linked to DNA damage and morphological changes caused by particulate matter

New method designs high-affinity, orally bioavailable peptides

Degron Therapeutics announced as winner of AFCR's 2023 BRACE Award Venture Competition

Genetic clue to pericarditis inflammation points to promising new treatments

Your unique microbiome may be used to improve and personalize your future medical experience

Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions

Common inflammation pathway turns anthrax toxin into killer

Research reveals how "forever chemicals" damage DNA at the molecular level

Researchers receive two grants to study tuberculosis drug development

Fox urine compound effectively repels flies through multisensory activation

Study identifies two stem cell types driving jellyfish tentacle growth

Study reveals how tiny tweaks to actin shape our cells

New family of polymers can kill bacteria without inducing antibiotic resistance

Boosting egg production in fruit flies through gut bugs

How medical manufacturing trends are evolving: From performance testing to 3D vision

Utilizing firefly liquid handling for laboratory developed tests

Immunopeptidomics offer new hope in cancer research

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