Virus-like particles (VLPs) are nanoscale particles, approximately 100–300 nm in diameter, formed by self-assembly of viral capsid proteins, which lack viral genetic material, cannot replicate independently, and are safer during production.
VLPs can display membrane proteins in their full natural conformation on the surface of virus-like particles, resulting in full-length transmembrane proteins suitable for immunization and antibody screening. The formation of VLP is depicted in Figure 1.
Figure 1. The formation of a virus-like particle (VLP). Image Credit: Sino Biological Inc.
Monoclonal and bispecific antibodies targeting GPRC5D, Claudins (Claudin 6 and Claudin 18), SSTR2, and CXCR4 have shown promising preclinical and clinical results in CAR-T cell therapy. Full-length versions of these multi-pass transmembrane proteins are still challenging to produce.
To enable targeted drug research, Sino Biological has created a VLP protein platform based on the HEK293 expression system for producing full-length multi-pass transmembrane proteins (e.g. GPRC5D).
Featured VLP proteins
Sino Biological offers GPRC5D, Claudin 6, Claudin 18, SSTR2, and other VLP proteins to researchers working on cancer immunotherapy.
Human claudin 6-VLP protein. Cat#: 16658-HNAH
Immobilized human claudin 6 protein can bind anti-claudin6 antibody. Image Credit: Sino Biological Inc.
Freeze-thaw stability. Image Credit: Sino Biological Inc.
Batch-to-batch Consistency. Image Credit: Sino Biological Inc.
Human GPRC5D-VLP protein. Cat#: 24447-HNAH
Immobilized human GPRC5D protein can bind anti-GPRC5D antibody. Image Credit: Sino Biological Inc.
Batch-to-batch Consistency. Image Credit: Sino Biological Inc.
Human GPRC5D protein, biotinylated. Cat#: 24447-HNAH-B.
Immobilized human GPRC5D protein can bind anti-GPRC5D antibody. Image Credit: Sino Biological Inc.
Human SSTR2/SSTR2A protein-VLP. Cat#: 11644-HNAH
Immobilized human SSTR2/SSTR2A protein can bind anti-SSTR2 antibody. Image Credit: Sino Biological Inc.
Human SSTR2/SSTR2B protein-VLP. Cat#: 30097-HNAH
Immobilized human SSTR2/SSTR2B protein can bind anti-SSTR2 antibody. Image Credit: Sino Biological Inc.
Human claudin 18.2-VLP protein. Cat#: 30025-HNAH
Immobilized human claudin 18.2 protein can bind anti-claudin18.2 antibody. Image Credit: Sino Biological Inc.
Human CXCR4/CD184 protein-VLP. Cat#: 11325-HNAH
Immobilized human CXCR4/CD184 protein can bind anti-CXR4/CD184 antibody. Image Credit: Sino Biological Inc.
More VLP proteins
Other CAR-T-related proteins
- MUC1
- CD8
- ICAM-1
- BCMA
- FAP
- PSMA
- CEACAM1
- CEACAM5
- CEACAM6
- CD137
- Claudin 11
- HER2
- IL-1
- IL-6
- IL-12