Macrocyclic compounds: A promising class of drugs for cancer treatment

This review was designed by Professor Xiaoling Song and Professor Biao Jiang and written by Pr. Xiaoling Song and a Ph.D. student, Yifan Wu (Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University) to summarize the application of macrocyclic molecules in cancer treatment. Macrocyclic compounds are cyclic molecules with a structure of 12 or more atoms. In the past decades, macrocycles have received increasing attention in drug development. The U.S. Food and Drug Administration has approved several macrocyclic drugs for cancer therapy. However, the importance of this class of cancer drugs is still not widely known.

Song and Wu comprehensively summarized the applications of both FDA-approved macrocyclic drugs in the past 15 years and those promising macrocyclic small molecules currently under development for cancer therapy, providing strong evidence for the applications of macrocyclic compounds in cancer treatment (Figure). First, macrocyclic molecules can target proteins critical for tumorigenesis or cancer development. Macrocyclic compounds can block nearly 80% of cancer's signature characteristic events to control cancer occurrence and progression, suggesting a space for using macrocyclic compounds in cancer therapy. Secondly, macrocyclic compounds can effectively overcome drug resistance caused by on-target mutations in targeted cancer therapy. Small compact macrocyclic molecules can enter the binding pocket, bind to mutant proteins, and inhibit their activities, especially those with resistant mutations around the binding pocket. These macrocyclic compounds developed recently for overcoming cancer drug resistance include the pyrazole- or pyrimidine-based TRK inhibitor Selitrectinib and the next-generation ROS1/ NTRK inhibitor Repotrectinib (TPX-0005).

Additionally, the authors reviewed the ongoing clinical trials for these novel macrocyclic drug candidates, and some of them have shown excellent therapeutic efficacy. For example, recent data from the latest Phase 1/2 clinical trial showed that first-line use of repotrectinib in ROS1-positive TKI-naïve lung cancer patients resulted in long-term progression-free survival (PFS) of 35.7 months (TRIDENT-1, NCT03093116. Byoung Chul Cho, et al. 2023 WCLC. OA 03.06).

Finally, Song and Wu provided novel insights into macrocyclic molecular drugs regarding their future directions, limitations, and combinational therapy with other drugs in clinics. This comprehensive review is beneficial for the development of novel cancer treatment strategies.

Journal reference:

Song, X., et al. (2023) Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance. MedComm - Oncology.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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