T helper 17 (Th17) cells generate the pro-inflammatory cytokine interleukin-17 (IL17/IL17A). IL17 has been a target for a variety of therapeutic monoclonal antibodies and inhibitors to treat different inflammatory diseases and cancers due to its vital functions in immune control.
IL17 is part of a cytokine family that includes five other members: IL17B, IL17C, IL17D, IL17E/IL25 and IL17F. The sequences of IL17 and IL17F are the most similar. To signal through the receptor complex constituted of the subunits of IL17RA and IL17RC, IL17 and IL17F form homodimers and heterodimers (IL17A & IL17F). Both IL17 and IL17F have a role in attracting neutrophils to inflammatory areas.
The production of cytokines (IL-1β, TNFα, G-CSF, IL-6, etc.), chemokines (MCP-1/CCL2, CXCL1, CXCL2, CCL20, etc.), inflammatory effectors and antimicrobial proteins can be induced by IL17 and IL17F signaling.
At least two more ligands, IL17C and IL17E, utilize the IL17RA subunit. IL17RB, IL17RC, IL17RD and IL17RE are all members of the IL17 Receptor family. To aid in the research of the IL17 family of cytokines and receptor proteins, Sino Biological has created a panel of high-quality recombinant cytokines and receptor proteins, as well as antibodies.
Recombinant IL17 cytokines
Sino Biological has created bioactive recombinant IL17 cytokines from a variety of species, including humans, mice, cynomolgus, rats, ferrets and canines.
Recommended recombinant IL-17A cytokines
Source: Sino Biological Inc.
| Catalog # |
Molecule |
Species |
Tag |
Expressed Host |
Activity |
| 12047-H07B |
IL17A |
Human |
N-His |
Insect Cells |
Active |
| 12047-H07Y |
IL17A |
Human |
N-His |
Yeast Cells |
Active |
| 12047-HNAE |
IL17A |
Human |
Native |
E. coli Cells |
Active |
| 12047-HNAS |
IL17A |
Human |
Native |
CHO Cells |
Active |
| 51065-MNAE |
IL17A |
Mouse |
Native |
E. coli Cells |
Active |
| 65006-T07B |
IL17A |
Rabbit |
N-His |
Insect Cells |
Active |
| 65006-TNAE |
IL17A |
Rabbit |
Native |
E. coli Cells |
Active |
| 70102-DNAE |
IL17A |
Canine |
Native |
E. coli Cells |
Active |
| 90287-CNAE |
IL17A |
Marmoset |
Native |
E. coli Cells |
Active |
| 90306-KNAB |
IL17A |
Rhesus |
Native |
Insect Cells |
Active |
| 90880-CNAB |
IL17A |
Cynomolgus |
Native |
Insect Cells |
|
| CT047-H08H |
IL17A & IL17F |
Human |
C-His |
HEK293 Cells |
Active |
| CT047-HNAE |
IL17A & IL17F |
Human |
Native |
E. coli Cells |
Active |
| CT063-K08H |
IL17A & IL17F |
Rhesus |
C-His |
HEK293 Cells |
|
Ability to induce IL-6 Secretion by NIH-3T3 mouse embryonic fibroblast cells in the presence of TNFα
Human IL17 Protein | 12047-HNAE. Image Credit: Sino Biological Inc
Human IL17A & IL17F Heterodimer | CT047-HNAE. Image Credit: Sino Biological Inc
Binding ability tested by ELISA
Rabbit IL17 Protein | 65006-T07B. Immobilized rabbit IL17A binds to rat IL17RA(Cat: 80190-R02H). Image Credit: Sino Biological Inc
Mouse IL17 Protein | 51065-MNAE. Immobilized mouse Il17A binds to mouse IL17RA(Cat: 50328-M08H). Image Credit: Sino Biological Inc
Recombinant IL17 receptors
- IL17RA
- IL17RB
- IL17RC
- IL17RD
Other related proteins
- IL17B
- IL17C
- IL17E/IL25
- IL17F
Antibodies for IL17 cytokines and receptors
Sino Biological has created a complete panel of antibodies that target IL17 cytokines and receptors for usage in ELISA, WB, Neutralization, FCM, IP and IHC. ELISA antibody pairs that are matched are also available.
- Anti-IL17B
- Anti-IL17C
- Anti-IL17E/IL25
- Anti-IL17F
- Anti-IL17RA
- Anti-IL17RB
- Anti-IL17RC
- Anti-IL17RD
IL17 / IL17A Neutralizing Antibody12047-M237. Image Credit: Sino Biological Inc