Hematology - Jan 3, 2024 - Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions

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	Hematology
	The latest hematology news from News Medical

	Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions Research delves into the complex roles of neutrophils in inflammatory bowel disease (IBD), exploring their diverse functions and interactions with the gut microbiota and emphasizing the need for targeted therapies based on these insights.

	Groundbreaking genome-editing technique holds promise for treating Charcot–Marie–Tooth disease Scientific advances in the last century have changed our world significantly. For example, the world of genetics has opened doors to a myriad of possibilities: augmented human capabilities, cures for diseases, and even changes to the course of evolution.

			3D-printed bone: Biomimetic scaffolds offer hope for cranial defect repair The cranial bone in the human body performs very important functions, such as protecting the brain and enabling the passage of the cranial nerves that are essential to physiological functioning.

			Common inflammation pathway turns anthrax toxin into killer Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system.

			Embryonic immune sensor could key to creating patient-derived blood stem cells A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

	GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

	A protein identified as key player in keeping cells tidy Just as healthy organs are vital to our well-being, healthy organelles are vital to the proper functioning of the cell.

	How 3D DNA architecture shapes cell fate in early embryos The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time.

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