Interleukin 21 (IL-21) belongs to the IL-2 class of cytokines strongly linked to autoimmunity and inflammation. Moreover, it has divergent impacts on lymphomas and lymphoid cell leukemia. Clinical trials using IL-21 have provided favorable outcomes in cancer treatment, while the development of IL-21 inhibitors is ongoing for the treatment of autoimmune diseases.
The significant sources of IL-21 are activated CD4+ T cells, such as natural killer (NK) T cells and T follicular helper (Tfh) cells. IL-21’s biological functions are interposed through a heterodimeric receptor including the IL-21R and the common γ-chain (γc/CD132) receptor.
The latter is shared with other cytokines from the IL-2 family (IL‐4, IL‐7, IL‐9 and IL‐15). The IL-21/IL-21R signaling triggers the Janus kinases (JAK1/JAK3), and then the STATs (STAT1/STAT3/STAT5) signaling pathways, to control the differentiation, proliferation, survival and functions of myeloid, lymphoid and epithelial cells.
Sino Biological has come up with a sequence of high-quality recombinant IL-21 and receptor proteins for the study of this cytokine.
Recombinant IL-21 cytokines and receptors
Sino Biological has specifically developed bioactive recombinant IL-21 cytokines obtained from numerous species, like mouse, rat, human and canine.
Featured IL-21 protein
Human IL-21 protein: 10584-HNAE: High purity, HPLC-verified, low endotoxin, high purity.
>95% as determined by SEC-HPLC. Image Credit: Sino Biological Inc.
Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.
Batch-to-batch Consistency. Image Credit: Sino Biological Inc.
Other recombinant IL-21 cytokines
Table 1. Source: Sino Biological Inc.
| Cat# |
Species |
Tag |
Expressed Host |
Purity |
Activity |
| 50137-MNAE |
Mouse |
Native |
E. coli |
>97% |
Active |
| 70016-DNAE |
Canine |
Native |
E. coli |
>97% |
Active |
| 80200-R08B |
Rat |
C-His |
Insect Cells |
>90% |
Active |
| 80200-RNAE |
Rat |
Native |
E. coli |
>95% |
|
Recombinant IL-21 receptor: IL-12R
Table 2. Source: Sino Biological Inc.
| Cat# |
Species |
Tag |
Activity |
| 11483-H02H |
Human |
C-hFc |
|
| 11483-H08H |
Human |
C-His |
Active |
| 51184-M02H |
Mouse |
C-hFc |
|
| 51184-M08H |
Mouse |
C-His |
|
| 80189-R05H |
Rat |
C-hFc |
|
| 80189-R08H |
Rat |
C-His |
Active |
| 90315-C02H |
Cynomolgus, Rhesus |
C-hFc |
Active |
| 90315-C08H |
Cynomolgus |
C-His |
|
Ability to inhibit IL-21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.
Other related proteins
- IL-4
- IL-7
- IL-9
- IL-15
- CD132
Antibodies for IL-21 cytokines and receptors
Sino Biological has come up with an extensive panel of antibodies that target IL-21 cytokines and receptors. This can be utilized in IHC, WB and ELISA.