High throughput (HT) gene-to-antibody manufacturing is the most economical choice for small-scale recombinant antibodies. Small-scale projects can be finished in as little as 10 business days with the help of GenScript’s high throughput gene synthesis platform and unique TurboCHO™ transient expression technology.
Small-scale projects begin with customer-supplied sequences and end with purified products.
A vast capacity of 10,000+ targets/month makes it possible to hasten medicines' development and global commercialization. Various purified antibody products, including IgGs, Fab, scFv, VHH, bi-specific antibodies, and more, can be delivered in large quantities (i.e., from ug to mg) using the TurboCHO™ High Throughput platform.
The automated technology assisting the TurboCHO™ High Throughput platform eliminates lot-to-lot variation and guarantees a high expression level.
Image Credit: GenScript
Highlights
- Availability of multiple isotypes
- Large capacity
- Fast delivery in 2 weeks
General workflow
Image Credit: GenScript
Service specifications
Source: GenScript
| Perspective |
Description |
| Targeting Amount (mAb) |
- 0.1 - 5 mg
- Other amounts upon request
|
| Turnaround Time |
As short as 2 weeks |
| Target Types |
- Recombinant proteins
- Antibody formats including full-length antibody, Fabs, scFvs, VHHs, or other fragments fused with Fc
|
| QC |
- SDS-PAGE
- Endotoxin control
- LC-MS
- Additional QC options available upon request with charge
|
| Purification |
- 1-step purification (Protein A for antibody targets)
- Additional purification options available upon request with charge
|
| Additional Services |
ELISA, Cell-based assay, FACS screening, Octet® BLI assay, Biacore™ SPR assay, etc. |
Note:
1. A minimum sample size of 8 is typically needed.
2. 5% of the samples will be chosen randomly for the LC-MS and endotoxin test.
Case studies
High expression titers in multiple isotypes
Image Credit: GenScript
High-purity of antibodies expressed in TurboCHO™ high throughput system
Image Credit: GenScript