Tumor-infiltrating lymphocytes and other T cell-mediated treatments, such as CAR-T, have the potential to improve the effectiveness and personalization of cancer care. Cytokines play a crucial part in T cell survival, development, and differentiation.
T cell therapies typically entail the removal of autologous T cells from patients, cell manipulation/engineering, culture expansion, and re-infusion into the patient. A single administration of adoptive T cell therapy can necessitate billions of expanded T cells.
To produce the highest output of T cells while maintaining the correct phenotypic and function, high-quality cytokines must be used.
A powerful cytokine called interleukin-2 (IL-2) is frequently utilized in T cell culture to encourage the proliferation and differentiation of T cells into effector and memory cells.
Other c-cytokines, including IL4, IL-7, IL-15, and IL-21, play a vital role in memory T cell development, proliferation, and survival. Varying combinations of IL-2, IL-7, IL-15, and IL-21 have been shown to efficiently expand T cells, resulting in populations expressing early-differentiation markers, such as CD27, CD28, CD62L, and CD127.
To enhance a particular T cell phenotype, culture conditions can be adjusted. For instance, Th1 needs IL-12, Th2 needs IL-4, Tregs need TGF-β1, and Th17 needs IL-6.
Image Credit: Sino Biological Inc.
To promote the use of cytokines in T cell-mediated therapies, Sino Biological has created an extensive collection of high-quality cytokines:
- HPLC Verified
- High Activity
- Various Species
- Low Endotoxin
- High Purity
Featured Cytokines
> 95 % as determined by SEC-HPLC. Image Credit: Sino Biological Inc.
Cell proliferation assay using CTLL-2 mouse cytotoxic T cells. Image Credit: Sino Biological Inc.
Human IL-4 Protein Cat#: 11846-HNAE
Cell proliferation assay using TF1 human erythroleukemic cells. Image Credit: Sino Biological Inc.
Human IL-7 Protein Cat#: 11821-HNAE
> 95 % as determined by SEC-HPLC. Image Credit: Sino Biological Inc.
Cell proliferation assay using anti-CD3 antibody activated human peripheral blood mononuclear cell (PBMC). Image Credit: Sino Biological Inc.
Human IL-21 Protein Cat#: 10584-HNAE
Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. Image Credit: Sino Biological Inc.
Human IL-6 Protein Cat#: 10395-HNAE
Cell proliferation assay using TF-1 human erythroleukemic cells. Image Credit: Sino Biological Inc.
Immobilized Human IL-6 can bind Human IL-6R (Cat: 10398-H02H). Image Credit: Sino Biological Inc.
Human IL-15 Protein Cat#: 10360-HNCE
Cell proliferation assay using MO7e human megakaryocytic leukemic cells. Image Credit: Sino Biological Inc.
Source: Sino Biological Inc.
| Cat# |
Species |
Cytokine |
Expression Host |
Tag |
Purity |
Activity |
| 11848-H08H |
Human |
IL2 |
HEK293 Cells |
C-His |
> 95 % |
|
| 11848-HNAH1-E |
Human |
|
HEK293 Cells |
Native |
> 95 % (HPLC verified) |
Active |
| 51061-MNAE |
Mouse |
|
E. coli |
Native |
> 92 % |
Active |
| 70014-DNAE |
Canine |
|
E. coli |
Native |
> 95 % |
Active |
| 80075-RNAE |
Rat |
|
E. coli |
Native |
> 95 % |
Active |
| 11846-HNAE |
Human |
IL4 |
E. coli |
Native |
> 92 % |
Active |
| 11846-HNAE-B |
Human |
|
E. coli |
Native |
> 90 % |
|
| 51084-M08B |
Mouse |
|
Baculovirus-Insect Cells |
C-His |
> 95 % |
Active |
| 51084-MNAE |
Mouse |
|
E. coli |
Native |
> 90 % |
Active |
| 70021-DNAE |
Canine |
|
E. coli |
Native |
> 96 % |
Active |
| 10395-HNAE |
Human |
IL6 |
E. coli |
Native |
≥ 95 % |
Active |
| 50136-MNAE |
Mouse |
|
E. coli |
Native |
> 90 % |
Active |
| 62006-WNAE |
Sus scrofa (Pig) |
|
E. coli |
Native |
> 95 % |
Active |
| 80076-RNAE |
Rat |
|
E. coli |
Native |
> 85 % |
Active |
| 90197-CNAE |
Rhesus |
|
E. coli |
Native |
> 85 % |
Active |
| 11821-HNAE |
Human |
IL7 |
E. coli |
Native |
> 95 % (HPLC verified) |
Active |
| 50217-MNAE |
Mouse |
|
E. coli |
Native |
> 90 % |
Active |
| 80329-RNAE |
Rat |
|
E. coli |
Native |
> 90 % |
Active |
| CT011-H08H |
Human |
IL12 |
HEK293 Cells |
C-His |
> 95 % |
Active |
| CT011-H08H-B |
Human |
|
HEK293 Cells |
C-His |
> 95 % |
|
| CT021-M02H |
Mouse |
|
HEK293 Cells |
C-hFc |
> 85 % |
Active |
| CT022-M08H |
Mouse |
|
HEK293 Cells |
C-His |
> 90 % |
Active |
| CT023-M0802H |
Mouse |
|
HEK293 Cells |
C-His & C-hFc |
> 85 % |
Active |
| CT024-M0208H |
Mouse |
|
HEK293 Cells |
C-His & C-hFc |
> 85 % |
Active |
| CT045-C08H |
Rhesus |
|
HEK293 Cells |
C-His |
> 95 % |
|
| CT050-H08H |
Human |
|
HEK293 Cells |
C-His |
> 95 % |
Active |
| CT050-HNAH |
Human |
|
HEK293 Cells |
Native |
> 95 % |
Active |
| 10360-H07E |
Human |
IL15 |
E. coli |
N-His |
> 95 % |
Active |
| 10360-HNCE |
Human |
|
E. coli |
N-cleavage |
> 95 % |
Active |
| 10584-HNAE |
Human |
IL21 |
E. coli |
Native |
> 95 % (HPLC verified) |
Active |
| 50137-MNAE |
Mouse |
|
E. coli |
Native |
> 97 % |
Active |
| 70016-DNAE |
Canine |
|
E. coli |
Native |
> 97 % |
Active |
| 80200-R08B |
Rat |
|
Baculovirus-Insect Cells |
C-His |
> 90 % |
Active |
| 80200-RNAE |
Rat |
|
E. coli |
Native |
> 95 % |
|
Other Related Proteins
- CD127
- CD27
- BCMA
- CD62L
- TGF-β1
- CD28
- CD19