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The recurrent β chain signaling cytokines — granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3 and IL-5 — can control the growth, activities and differentiation of eosinophils and other hematopoietic cells.

Therapeutic approaches to control such cytokines have been approved for use in several cancers as well as allergic and autoimmune diseases, while others exhibit potential early clinical activity.

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Generally, cytokine heterodimeric receptors consist of two or three subunits: a significant ligand-binding subunit (the α subunit) and a signaling subunit (the β or γ subunit). This is epitomized by the common β-chain (CD131/ βc) of GM-CSF, IL-3 and IL-5 receptors; the gp130 (shared by the receptors for IL-6, IL-11), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) and cardiotrophin; and the common IL-2 receptor γ-chain (shared by the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors).

Sino Biological has come up with a series of bioreagents to aid the study of β common chain cytokines and other significant cytokines and receptors.

βc family cytokines and receptors

The high-activity cytokine and receptor proteins from Sino Biological are obtained from several species and help study the biology of common β chain signaling cytokines.

Mouse IL-3 Protein, Tag Free—51066-MNAH. Cell proliferation assay using NFS-60 mouse myelogenous leukemia lymphoblast cells.

Mouse IL-3 Protein, Tag Free — 51066-MNAH. Cell proliferation assay using NFS-60 mouse myelogenous leukemia lymphoblast cells. Image Credit: Sino Biological Inc.

Human IL-5 Protein, N-cleavage—5673-HNCE. Cell proliferation assay using TF-1 human erythroleukemic cells.

Human IL-5 Protein, N-cleavage — 5673-HNCE. Cell proliferation assay using TF-1 human erythroleukemic cells. Image Credit: Sino Biological Inc.

Human GM-CSF Protein—10015-HNAH. Cell proliferation assay using TF-1 human erythroleukemic cells.

Human GM-CSF Protein — 10015-HNAH. Cell proliferation assay using TF-1 human erythroleukemic cells. Image Credit: Sino Biological Inc.

Human CSF2RB/CD131 Protein—10516-H08H. Binding ability by ELISA. Immobilized human CD131 at 10 μg/mL (100 μL/well) can bind human Fc-GMCSF (Cat: 10015-H01H).

Human CSF2RB/CD131 Protein — 10516-H08H. Binding ability by ELISA. Immobilized human CD131 at 10 μg/mL (100 μL/well) can bind human Fc-GMCSF (Cat: 10015-H01H). Image Credit: Sino Biological Inc.

Recommended βc family cytokine and receptor proteins

IL-3 and IL-3 receptor proteins

Table 1. Source: Sino Biological Inc.

Catalog Species Molecule Tag Expression Host Activity
11858-H08H Human IL-3 C-His HEK293 Cells Active
11858-HNAE Human IL-3 Native E. coli Active
51066-MNAH Mouse IL-3 Native HEK293 Cells Active
80235-R08B Rat IL-3 C-His Insect Cells Active
10518-H02H Human IL3Ra C-hFc HEK293 Cells  
10518-H08H Human IL3Ra C-His HEK293 Cells  
50810-M02H Mouse IL3Ra C-hFc HEK293 Cells  
50810-M08H Mouse IL3Ra C-His HEK293 Cells  
70077-D08H Canine IL3Ra C-His HEK293 Cells  

 

IL-5 and IL-5 receptor proteins

Table 2. Source: Sino Biological Inc.

Catalog Species Molecule Tag Expression Host Activity
15673-HNAH Human IL-5 Native HEK293 Cells  
15673-HNCE Human IL-5 N-cleavage E. coli Active
70019-D08B Canine IL-5 C-His Insect Cells Active
51154-M08B Mouse IL5RA C-His Insect Cells Active

 

GM-CSF and receptor proteins

Table 3. Source: Sino Biological Inc.

Catalog Species Molecule Tag Expression Host Activity
10015-H07H Human GM-CSF/CSF2 N-His HEK293 Cells Active
10015-HNAH-B Human GM-CSF/CSF2 Native HEK293 Cells  
51048-M01H Mouse GM-CSF/CSF2 N-hFc HEK293 Cells Active
51048-M07H Mouse GM-CSF/CSF2 N-His HEK293 Cells Active
51048-MNAH Mouse GM-CSF/CSF2 Native HEK293 Cells Active
80020-R01H Rat GM-CSF/CSF2 N-hFc HEK293 Cells Active
80020-R07H Rat GM-CSF/CSF2 N-His HEK293 Cells Active
10701-H02H Human CSF2RA C-hFc HEK293 Cells Active
10701-H08H Human CSF2RA C-His HEK293 Cells Active
10516-H08H Human CD131/CSF2RB C-His HEK293 Cells Active
80323-R02H Rat CD131/CSF2RB C-hFc HEK293 Cells  

 

βc cytokine family antibodies

Sino Biological has come up with an extensive panel of antibodies that target the common β chain signaling cytokines and receptors. These antibodies can be utilized in FCM, ELISA, IHC, IP and WB. The company also offers human and mouse ELISA pair sets.

  • Anti-IL3
  • Anti-IL5
  • Anti-IL3RA
  • Anti-IL5RA
  • Anti-GM-CSF
  • Anti-CSF2RA/CD116
  • Anti-CSF2RB/CD131