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ANGPT2/TIE2: Therapeutic targets for anti-angiogenic cancer treatment

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Angiopoietin-2, or ANGPT2, is known to be a ligand of the TIE2 receptor tyrosine kinase (TEK). Signaling of ANGPT2-TIE2 triggers vascular sprouting by working together with vascular endothelial growth factor, or VEGF.

ANGPT2 suppression exhibits prospective results in inhibiting tumor growth, tumor angiogenesis and metastasis in preclinical models. This makes it a promising candidate to target for cancer treatment.

Learn More about ANGPT/TIE2 Reagents

Angiopoietins are a class of secreted factors that include ANGPT1, ANGPT2, ANGPT3 (ANGPTL1), ANGPT4, ANGPT5 (ANGPTL3), ANGPTL2, ANGPTL4, ANGPTL5, ANGPTL6 and ANGPTL7. While ANGPT1 is a potent activator of TIE2, ANGPT2 acts as a context-dependent agonist/antagonist.

During the early stages of tumor progression, ANGPT2 is highly upregulated to induce neovessel formation. Traditional anti-VEGF therapies mainly target immature blood vessels in tumors.

Currently, it is predicted that the combinational targeting of both VEGF and ANGPT2 pathways enhances clinical efficacy by widening the target vessel population. Sino Biological has come up with reagents of high quality to promote the study of ANGPT2/TIE2 signaling.

ANGPT2/TIE2 pathway proteins

Sino Biological has designed a series of high-activity TIE2 and ANGPT2 proteins from different species for analyzing the biology of the ANGPT2/TIE2 pathway.

Binding ability measured by ELISA. Immobilized Rhesus TIE2 His (Cat: 90292-C08H) at 2 µg/mL (100 µL/well) can bind Cynomolgus, Rhesus Angiopoietin-2. The EC50 is 6.0-48.0 ng/mL.

Binding ability measured by ELISA. Immobilized Rhesus TIE2 His (Cat: 90292-C08H) at 2 µg/mL (100 µL/well) can bind Cynomolgus, Rhesus Angiopoietin-2. The EC50 is 6.0-48.0 ng/mL. Image Credit: Sino Biological Inc.

Binding ability measured by ELISA.

Binding ability measured by ELISA. Immobilized recombinant human Angiopoietin-2 at 10 µg/mL (100 μL/well) can bind Human Tie2 / Fc chimera with a range of 0.2-20 µg/mL. Image Credit: Sino Biological Inc.

Recommended ANGPT2/TIE2 proteins

Source: Sino Biological Inc.

Molecule Catalog # Species Tag Expressed Host Activity
ANGPT2 10691-H02H Human C-hFc HEK293 Cells Active
ANGPT2 10691-H38H1 Human C-mFc HEK293 Cells  
ANGPT2 70034-D07H Canine N-His HEK293 Cells Active
ANGPT2 90026-C01H Cynomolgus, Rhesus N-hFc HEK293 Cells Active
ANGPT2 90026-C07H Cynomolgus, Rhesus N-His HEK293 Cells Active
ANGPT2 90026-C08H Cynomolgus, Rhesus C-His HEK293 Cells  
Tie2 10700-H03H Human C-hFc & His HEK293 Cells Active
Tie2 10700-H08H Human C-His HEK293 Cells Active
Tie2 10700-H08H-B Human C-His HEK293 Cells  
Tie2 10700-H20B1 Human N-GST & His Insect Cells Active
Tie2 51087-M02H Mouse C-hFc HEK293 Cells Active
Tie2 51087-M08H Mouse C-His HEK293 Cells Active
Tie2 51087-M20B1 Mouse N-GST & His Insect Cells Active
Tie2 80063-R02H Rat C-hFc HEK293 Cells Active
Tie2 90292-C02H Cynomolgus C-hFc HEK293 Cells Active
Tie2 90292-C08H Rhesus C-His HEK293 Cells  

 

Other related proteins

  • TIE1
  • ANGPT1
  • ANGPTL1, or ANGPT3
  • ANGPT4
  • ANGPTL3, or ANGPT5
  • ANGPTL2
  • ANGPTL4
  • ANGPTL5
  • ANGPTL7

ANGPT2/TIE2 pathway antibodies

Sino Biological has created an all-inclusive range of antibodies that target ANGPT2/TIE2 and associated molecules, which can be used in WB, FCM, ICC/IF, ELISA and IP. The company also offers ELISA pair sets and ELISA kits.

  • Anti-Tie2
  • Anti-ANGPT2